顶复门寄生虫中的蛋白质棕榈酰化与发病机制
Protein palmitoylation and pathogenesis in apicomplexan parasites.
作者信息
Corvi Maria Martha, Alonso Andres Mariano, Caballero Marina Cecilia
机构信息
Laboratorio de Parasitologia Molecular, Instituto Tecnológico de Chascomús (IIBINTECH), CONICET-Universidad Nacional de General San Martín, Intendente Marino Km 8,2, P.O. Box 164, Chascomús, B7130IWA Buenos Aires, Argentina.
出版信息
J Biomed Biotechnol. 2012;2012:483969. doi: 10.1155/2012/483969. Epub 2012 Oct 3.
Abstract
Apicomplexan parasites comprise a broad variety of protozoan parasites, including Toxoplasma gondii, Plasmodium, Eimeria, and Cryptosporidium species. Being intracellular parasites, the success in establishing pathogenesis relies in their ability to infect a host-cell and replicate within it. Protein palmitoylation is known to affect many aspects of cell biology. Furthermore, palmitoylation has recently been shown to affect important processes in T. gondii such as replication, invasion, and gliding. Thus, this paper focuses on the importance of protein palmitoylation in the pathogenesis of apicomplexan parasites.
摘要
顶复门寄生虫包括多种原生动物寄生虫，如弓形虫、疟原虫、艾美耳球虫和隐孢子虫属。作为细胞内寄生虫，它们建立致病机制的成功依赖于感染宿主细胞并在其中复制的能力。已知蛋白质棕榈酰化会影响细胞生物学的许多方面。此外，最近已表明棕榈酰化会影响弓形虫的重要过程，如复制、入侵和滑行。因此，本文重点关注蛋白质棕榈酰化在顶复门寄生虫致病机制中的重要性。
相似文献
1
Protein palmitoylation and pathogenesis in apicomplexan parasites.
J Biomed Biotechnol. 2012;2012:483969. doi: 10.1155/2012/483969. Epub 2012 Oct 3.
2
Protein palmitoylation in protozoan parasites.
Front Biosci (Schol Ed). 2011 Jun 1;3(3):1067-79. doi: 10.2741/211.
3
Blocking Palmitoylation of Toxoplasma gondii Myosin Light Chain 1 Disrupts Glideosome Composition but Has Little Impact on Parasite Motility.
mSphere. 2021 May 19;6(3):e00823-20. doi: 10.1128/mSphere.00823-20.
4
Cytoskeleton of apicomplexan parasites.
Microbiol Mol Biol Rev. 2002 Mar;66(1):21-38; table of contents. doi: 10.1128/MMBR.66.1.21-38.2002.
5
Emerging roles for protein S-palmitoylation in Toxoplasma biology.
Int J Parasitol. 2014 Feb;44(2):121-31. doi: 10.1016/j.ijpara.2013.09.004. Epub 2013 Nov 1.
6
Apicomplexan parasite adhesins: novel strategies for targeting host cell carbohydrates.
Curr Opin Struct Biol. 2010 Oct;20(5):551-9. doi: 10.1016/j.sbi.2010.08.003. Epub 2010 Sep 16.
7
[The molecular mechanisms of erythrocyte invasion of Plasmodium spp. as a model organism of apicomplexan protozoa].
Turkiye Parazitol Derg. 2010;34(4):203-6. doi: 10.5152/tpd.2010.15.
8
Nutrient acquisition by intracellular apicomplexan parasites: staying in for dinner.
Int J Parasitol. 2001 Oct;31(12):1321-30. doi: 10.1016/s0020-7519(01)00258-2.
9
Dynamic protein S-palmitoylation mediates parasite life cycle progression and diverse mechanisms of virulence.
Crit Rev Biochem Mol Biol. 2017 Apr;52(2):145-162. doi: 10.1080/10409238.2017.1287161. Epub 2017 Feb 20.
10
Palmitoylation in apicomplexan parasites: from established regulatory roles to putative new functions.
Mol Biochem Parasitol. 2019 Jun;230:16-23. doi: 10.1016/j.molbiopara.2019.04.001. Epub 2019 Apr 9.
引用本文的文献
1
A novel yeast-based high-throughput method for the identification of protein palmitoylation inhibitors.
Open Biol. 2021 Aug;11(8):200415. doi: 10.1098/rsob.200415. Epub 2021 Aug 4.
2
The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites.
Cell Chem Biol. 2020 Feb 20;27(2):143-157.e5. doi: 10.1016/j.chembiol.2020.01.001. Epub 2020 Jan 23.
3
The Methods Employed in Mass Spectrometric Analysis of Posttranslational Modifications (PTMs) and Protein-Protein Interactions (PPIs).
Adv Exp Med Biol. 2019;1140:169-198. doi: 10.1007/978-3-030-15950-4_10.
4
Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite.
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7183-8. doi: 10.1073/pnas.1522381113. Epub 2016 Jun 14.
5
The Plasmodium palmitoyl-S-acyl-transferase DHHC2 is essential for ookinete morphogenesis and malaria transmission.
Sci Rep. 2015 Nov 3;5:16034. doi: 10.1038/srep16034.
6
Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans.
Prog Lipid Res. 2013 Oct;52(4):488-512. doi: 10.1016/j.plipres.2013.06.003. Epub 2013 Jul 1.
本文引用的文献
1
Gliding motility of Babesia bovis merozoites visualized by time-lapse video microscopy.
PLoS One. 2012;7(4):e35227. doi: 10.1371/journal.pone.0035227. Epub 2012 Apr 10.
2
Protein palmitoylation inhibition by 2-bromopalmitate alters gliding, host cell invasion and parasite morphology in Toxoplasma gondii.
Mol Biochem Parasitol. 2012 Jul;184(1):39-43. doi: 10.1016/j.molbiopara.2012.03.006. Epub 2012 Mar 30.
3
Identification and characterization of a novel Neospora caninum immune mapped protein 1.
Parasitology. 2012 Jul;139(8):998-1004. doi: 10.1017/S0031182012000285. Epub 2012 Mar 12.
4
Host cell invasion by apicomplexans: what do we know?
Trends Parasitol. 2012 Apr;28(4):131-5. doi: 10.1016/j.pt.2012.01.005. Epub 2012 Feb 10.
5
Toxoplasma gondii immune mapped protein-1 (TgIMP1) is a novel vaccine candidate against toxoplasmosis.
Vaccine. 2012 Mar 16;30(13):2282-7. doi: 10.1016/j.vaccine.2012.01.073. Epub 2012 Feb 3.
6
Global profiling of dynamic protein palmitoylation.
Nat Methods. 2011 Nov 6;9(1):84-9. doi: 10.1038/nmeth.1769.
7
Bioorthogonal chemical reporters for analyzing protein lipidation and lipid trafficking.
Acc Chem Res. 2011 Sep 20;44(9):699-708. doi: 10.1021/ar200063v. Epub 2011 Jun 15.
8
Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication.
Trends Parasitol. 2011 Sep;27(9):410-20. doi: 10.1016/j.pt.2011.04.002. Epub 2011 Jun 12.
9
Protein palmitoylation in protozoan parasites.
Front Biosci (Schol Ed). 2011 Jun 1;3(3):1067-79. doi: 10.2741/211.
10
The moving junction of apicomplexan parasites: a key structure for invasion.
Cell Microbiol. 2011 Jun;13(6):797-805. doi: 10.1111/j.1462-5822.2011.01597.x. Epub 2011 Apr 28.
Zotero 插件