评估他汀类药物使用对醋硝香豆素和苯丙香豆素维持剂量的影响。

Evaluation of the effect of statin use on the acenocoumarol and phenprocoumon maintenance dose.

作者信息

van Schie Rianne M F, Verhoef Talitha I, Boejharat Saskia B, Schalekamp Tom, Wessels Judith A M, le Cessie Saskia, Rosendaal Frits R, van der Meer Felix J M, de Boer Anthonius, Maitland-van der Zee Anke-Hilse

机构信息

sion of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

出版信息

Drug Metabol Drug Interact. 2012;27(4):229-34. doi: 10.1515/dmdi-2012-0024.

DOI:10.1515/dmdi-2012-0024

PMID:23096528

Abstract

BACKGROUND

Statins and coumarins are prescribed in combination on a regular basis. Some case reports suggested that statins might affect the dose requirements of coumarins. The aim of the study was to investigate whether acenocoumarol and phenprocoumon maintenance doses are influenced by statin use.

METHODS

The Pre-EU-PACT database was used, which contains information on 471 acenocoumarol and 624 phenprocoumon users. The influence of individual statins on the acenocoumarol and phenprocoumon maintenance dose was investigated by comparing unadjusted and adjusted mean differences of the maintenance dose between statin and non-statin users.

RESULTS

Lower adjusted acenocoumarol dose requirements were observed for patients using atorvastatin, simvastatin, pravastatin, and rosuvastatin. These patients had a reduction in adjusted mean acenocoumarol maintenance dose of 0.11, 0.29, 0.38, and 0.69 mg/day, respectively, compared with a mean adjusted dose of 2.60 mg/day for the patients not using a statin. There was no significant effect of statin use on unadjusted and adjusted phenprocoumon maintenance dose (p=0.23 and p=0.35, respectively).

CONCLUSIONS

Mean acenocoumarol maintenance dosages were decreased when acenocoumarol is co-administered with the different statins. Statin use does not affect phenprocoumon maintenance doses significantly.

摘要

背景

他汀类药物和香豆素类药物经常联合使用。一些病例报告表明，他汀类药物可能会影响香豆素类药物的剂量需求。本研究的目的是调查醋硝香豆素和苯丙香豆素的维持剂量是否受他汀类药物使用的影响。

方法

使用欧盟前PACT数据库，其中包含471名醋硝香豆素使用者和624名苯丙香豆素使用者的信息。通过比较他汀类药物使用者和非他汀类药物使用者维持剂量的未调整和调整后平均差异，研究了个体他汀类药物对醋硝香豆素和苯丙香豆素维持剂量的影响。

结果

使用阿托伐他汀、辛伐他汀、普伐他汀和瑞舒伐他汀的患者，观察到醋硝香豆素的调整后剂量需求较低。与未使用他汀类药物的患者平均调整剂量2.60毫克/天相比，这些患者的醋硝香豆素调整后平均维持剂量分别降低了0.11、0.29、0.38和0.69毫克/天。他汀类药物的使用对未调整和调整后的苯丙香豆素维持剂量没有显著影响（p分别为0.23和0.35）。