患有威德曼-贝克威思综合征的儿童的神经母细胞瘤。

Neuroblastoma in a child with Wiedemann-Beckwith syndrome.

作者信息

Chitayat D, Friedman J M, Dimmick J E

机构信息

Department of Medical Genetics, University Hospital Shaughnessy Site, University of British Columbia, Vancouver, Canada.

出版信息

Am J Med Genet. 1990 Mar;35(3):433-6. doi: 10.1002/ajmg.1320350322.

DOI:10.1002/ajmg.1320350322

PMID:2309794

Abstract

We report on a patient with Wiedemann-Beckwith syndrome (WBS) who developed abdominal neuroblastoma. Although WBS patients are known to have a higher incidence of embryonal tumors, this is only the 4th known case of neuroblastoma associated with this syndrome. Chromosomes on peripheral lymphocytes and tumor cells were normal. Children with WBS should be screened for a variety of embryonal neoplasms, not only Wilms tumor.

摘要

我们报告了一名患有威德曼-贝克威思综合征（WBS）并发生腹部神经母细胞瘤的患者。尽管已知WBS患者发生胚胎性肿瘤的几率较高，但这仅是已知的第4例与该综合征相关的神经母细胞瘤病例。外周淋巴细胞和肿瘤细胞的染色体均正常。患有WBS的儿童应筛查多种胚胎性肿瘤，而不仅仅是肾母细胞瘤。