蜗牛/ Gfi-1（SNAG）家族锌指蛋白在转录调控、染色质动力学、细胞信号转导、发育和疾病中的作用。
Snail/Gfi-1 (SNAG) family zinc finger proteins in transcription regulation, chromatin dynamics, cell signaling, development, and disease.
机构信息
Department of Biological Sciences, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA.
出版信息
Cytokine Growth Factor Rev. 2013 Apr;24(2):123-31. doi: 10.1016/j.cytogfr.2012.09.002. Epub 2012 Oct 25.
Abstract
The Snail/Gfi-1 (SNAG) family of zinc finger proteins is a group of transcriptional repressors that have been intensively studied in mammals. SNAG family members are similarly structured with an N-terminal SNAG repression domain and a C-terminal zinc finger DNA binding domain, however, the spectrum of target genes they regulate and the ranges of biological functions they govern vary widely between them. They play active roles in transcriptional regulation, formation of repressive chromatin structure, cellular signaling and developmental processes. They can also result in disease states due to deregulation. We have performed a thorough investigation of the relevant literature and present a comprehensive mini-review. Based on the available information, we also propose a mechanism by which SNAG family members may function.
摘要
蜗牛/ Gfi-1（SNAG）家族的锌指蛋白是一组转录抑制剂，在哺乳动物中得到了深入研究。SNAG 家族成员具有相似的结构，具有 N 端 SNAG 抑制结构域和 C 端锌指 DNA 结合结构域，但是它们调节的靶基因谱和它们所控制的生物学功能范围在它们之间差异很大。它们在转录调节、抑制性染色质结构的形成、细胞信号转导和发育过程中发挥着积极的作用。由于失调，它们也可能导致疾病状态。我们对相关文献进行了彻底的调查，并提出了一个全面的综述。基于现有的信息，我们还提出了 SNAG 家族成员可能的作用机制。
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本文引用的文献
1
Characterization of the E-box binding affinity to snag-zinc finger proteins.
Mol Biol (Mosk). 2012 Nov-Dec;46(6):907-14.
2
Characterization of the SNAG and SLUG domains of Snail2 in the repression of E-cadherin and EMT induction: modulation by serine 4 phosphorylation.
PLoS One. 2012;7(5):e36132. doi: 10.1371/journal.pone.0036132. Epub 2012 May 2.
3
Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer.
Oncogene. 2013 Mar 14;32(11):1351-62. doi: 10.1038/onc.2012.169. Epub 2012 May 7.
4
A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain.
J Cell Sci. 2012 Feb 15;125(Pt 4):993-1002. doi: 10.1242/jcs.095877. Epub 2012 Mar 7.
5
Akt2 interacts with Snail1 in the E-cadherin promoter.
Oncogene. 2012 Sep 6;31(36):4022-33. doi: 10.1038/onc.2011.562. Epub 2011 Dec 12.
6
EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin.
Oncogene. 2012 Feb 2;31(5):583-94. doi: 10.1038/onc.2011.254. Epub 2011 Jun 20.
7
Expression of transcription factors snail, slug, and twist in human bladder carcinoma.
J Exp Clin Cancer Res. 2010 Sep 1;29(1):119. doi: 10.1186/1756-9966-29-119.
8
SNAI2/Slug promotes growth and invasion in human gliomas.
BMC Cancer. 2010 Jun 17;10:301. doi: 10.1186/1471-2407-10-301.
9
Slug inhibits proliferation of human prostate cancer cells via downregulation of cyclin D1 expression.
Prostate. 2010 Dec 1;70(16):1768-77. doi: 10.1002/pros.21213.
10
The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1.
EMBO J. 2010 Jun 2;29(11):1803-16. doi: 10.1038/emboj.2010.63. Epub 2010 Apr 13.
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