II型胶原蛋白治疗对佐剂诱导性关节炎大鼠免疫组织抗氧化状态的影响。
Effect of type II collagen treatment on the antioxidant status in immune tissues of adjuvant induced arthritic rats.
作者信息
Ganesan Nalini, Chegu Hariprasad, Chandrasekaran A N
机构信息
Dept. of Biochemistry, SRMC & RI (DU), Porur, 600 116 Chennai.
出版信息
Indian J Clin Biochem. 2003 Jul;18(2):216-22. doi: 10.1007/BF02867390.
Adjuvant induced arthritis (AIA) is a model widely used to study Rheumatoid arthritis (RA). In the present study, lipid peroxides level in spleen and thymus of AIA rats was observed to be significantly high compared to normal rats. A significant decrease in ascorbic acid (ASA), reduced glutathione (GSH), superoxide dismutase activity (SOD) was also observed in spleen and thymus of AIA rats compared to normal rats. There was also a steady increase in the circulating immune complex level (CIC) throughout the experimental period in serum of AIA rats. In the present investigation, it was decided to study the effect of pre and post treatment with TYPE II collagen on the antioxidant status and the circulating immune complex level in AIA rats. The results from the present work indicates that the pretreatment with TYPE II collagen was effective in bringing significant changes on all the parameters studied in AIA rats. The post treatment with TYPE II collagen was effective in bringing significant changes on the CIC immune complex level and GSH content in the thymus tissue of AIA rats. The present work suggests that the pre treatment with TYPE II collagen was more effective in suppressing the disease than the post treatment.
佐剂性关节炎（AIA）是一种广泛用于研究类风湿性关节炎（RA）的模型。在本研究中，观察到AIA大鼠脾脏和胸腺中的脂质过氧化物水平显著高于正常大鼠。与正常大鼠相比，AIA大鼠脾脏和胸腺中的抗坏血酸（ASA）、还原型谷胱甘肽（GSH）、超氧化物歧化酶活性（SOD）也显著降低。在整个实验期间，AIA大鼠血清中的循环免疫复合物水平（CIC）也持续升高。在本研究中，决定研究II型胶原蛋白治疗前后对AIA大鼠抗氧化状态和循环免疫复合物水平的影响。本研究结果表明，II型胶原蛋白预处理对AIA大鼠所有研究参数均有显著影响。II型胶原蛋白治疗后对AIA大鼠胸腺组织中的CIC免疫复合物水平和GSH含量有显著影响。本研究表明，II型胶原蛋白预处理比治疗后更有效地抑制疾病。
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