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[儿童和青少年抑郁症的心理药物治疗——自“黑框”警告以来的进展与标准]

[The psychopharmacological treatment of depressive disorders in childhood and adolescence - developments and standards since the «black box» warning].

作者信息

Plener Paul L, Fegert Jörg M, Kölch Michael G

机构信息

Klinik für Kinder- und Jugendpsychiatrie und Psychotherapie, Universität Ulm.

出版信息

Z Kinder Jugendpsychiatr Psychother. 2012 Nov;40(6):365-71. doi: 10.1024/1422-4917/a000196.

Abstract

Depending on symptom severity, psychopharmacological treatment can be a valuable option in the treatment of depressive disorders in childhood and adolescence. This review provides recommendations for clinical treatment, focusing on suicidality and treatment-resistant patients. The quality of studies regarding the psychopharmacological therapy of depressive disorders in childhood and adolescence has improved since the «black box» warning of the FDA concerning the occurrence of suicidality under treatment with selective serotonin reuptake inhibitors (SSRIs). In Germany, there is proof for a trend toward a more evidence-based psychopharmacological treatment approach within recent years.

摘要

根据症状严重程度,心理药物治疗对于儿童和青少年抑郁症的治疗可能是一种有价值的选择。本综述提供了临床治疗建议,重点关注自杀倾向和难治性患者。自美国食品药品监督管理局(FDA)针对选择性5-羟色胺再摄取抑制剂(SSRIs)治疗时出现自杀倾向发出“黑框”警告以来,关于儿童和青少年抑郁症心理药物治疗的研究质量有所提高。在德国,有证据表明近年来心理药物治疗方法有朝着更循证方向发展的趋势。

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