小鼠被动回避训练后，多种脑结构中5-溴-2'-脱氧尿苷掺入增加。

Increased 5-bromo-2'-deoxyuridine incorporation in various brain structures following passive avoidance training in mice.

作者信息

Ivashkina O I, Zots M A, Bezriadnov D V, Anokhin K V

机构信息

Laboratory of Neurobiology of Memory, PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2012 Sep;153(5):591-3. doi: 10.1007/s10517-012-1773-x.

DOI:10.1007/s10517-012-1773-x

PMID:23113232

Abstract

We studied the effects of training on DNA synthesis intensity in mouse brain. Brain cells where DNA synthesis-associated processes took place under the influence of training were detected by immunohistochemical labeling of DNA molecules with synthetic thymine analogue 5-bromo-2'-deoxyuridine. The number of 5-bromo-2'-deoxyuridine-positive cell increased in various structures of the brain under the influence of training.

摘要

我们研究了训练对小鼠大脑中DNA合成强度的影响。通过用合成胸腺嘧啶类似物5-溴-2'-脱氧尿苷对DNA分子进行免疫组织化学标记，检测了在训练影响下发生DNA合成相关过程的脑细胞。在训练的影响下，大脑各结构中5-溴-2'-脱氧尿苷阳性细胞的数量增加。