Coupe M, Rees H, Springer C J, Bishop A E, Morris J A, Polak J M, Calam J
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Gut. 1990 Feb;31(2):144-7. doi: 10.1136/gut.31.2.144.
Patients with hypergastrinaemic duodenal ulcer disease were studied to determine whether chronic moderate hypergastrinaemia produces hyperplasia of gastric enterochromaffin-like cells in man. Eight patients had peak postprandial plasma gastrin concentrations greater than 200 pmol/l, which is the 92nd percentile for patients with duodenal ulcer disease in this laboratory. The control group was eight patients with duodenal ulcers whose peak postprandial gastrin concentrations were less than 200 pmol/l. Basal and peak postprandial plasma gastrin concentrations were 107 (37) and 306 (66) pmol/l (mean (SEM] respectively in the hypergastrinaemic patients compared with 26 (4) and 137 (14) pmol/l respectively in the controls. There was no significant difference in the density of gastrin enterochromaffin-like cells between the two groups. The number of enterochromaffin-like cells per high power field was 53 (8) in the hypergastrinaemic patients compared with 50 (8) in the controls. We conclude that chronic moderate hypergastrinaemia does not produce hyperplasia of enterochromaffin-like cells in man. Our hypergastrinaemic group had plasma gastrin concentrations similar to, or greater than those reported during treatment with drugs such as omeprazole and histamine H2 receptor blockers.
对高胃泌素血症性十二指肠溃疡病患者进行了研究，以确定慢性中度高胃泌素血症是否会导致人类胃嗜铬样细胞增生。8例患者餐后血浆胃泌素峰值浓度大于200 pmol/l，这是该实验室十二指肠溃疡病患者的第92百分位数。对照组为8例十二指肠溃疡患者，其餐后胃泌素峰值浓度低于200 pmol/l。高胃泌素血症患者的基础和餐后血浆胃泌素峰值浓度分别为107（37）和306（66）pmol/l（均值（标准误）），而对照组分别为26（4）和137（14）pmol/l。两组之间胃泌素嗜铬样细胞的密度无显著差异。高胃泌素血症患者每高倍视野嗜铬样细胞数量为53（8），而对照组为50（8）。我们得出结论，慢性中度高胃泌素血症不会导致人类嗜铬样细胞增生。我们的高胃泌素血症组的血浆胃泌素浓度与使用奥美拉唑和组胺H2受体阻滞剂等药物治疗期间报告的浓度相似或更高。
