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Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts.
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p53 opens the mitochondrial permeability transition pore to trigger necrosis.
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Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.
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Cyclophosphamide dose intensification may circumvent anthracycline resistance of p53 mutant breast cancers.
Oncologist. 2010;15(3):246-52. doi: 10.1634/theoncologist.2009-0243. Epub 2010 Mar 12.
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Blinded by the Light: The Growing Complexity of p53.
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