不对称二甲基精氨酸与 2 型糖尿病患者颈动脉粥样硬化。
Asymmetric dimethylarginine and carotid atherosclerosis in Type 2 diabetes mellitus.
机构信息
Department of Cardiology, Qingdao Municipal Hospital, the Affiliated Hospital of Ocean University of China, Shandong, China.
出版信息
J Endocrinol Invest. 2012 Oct;35(9):824-7. doi: 10.1007/BF03347101.
BACKGROUND
Circulating asymmetric dimethylarginine (ADMA) concentration is elevated in patients with Type 2 diabetes mellitus (T2DM).
AIM
To assess the relationship between plasma ADMA concentration and carotid atherosclerosis in patients with T2DM.
SUBJECTS AND METHODS
A total of 72 newly diagnosed and untreated T2DM individuals and 72 healthy controls were studied. Carotid atherosclerosis was determined by ultrasonographically evaluated intima- media thickness (IMT) and plaque score. Plasma concentration of ADMA was measured by high-performance liquid chromatography.
RESULTS
Plasma ADMA, mean IMT, and plaque score were higher in diabetic patients compared with controls. Univariate and multivariate analyses demonstrated an independent association between ADMA and mean IMT in diabetic patients. On a multiple logistic regression analysis, ADMA was the sole predictor of carotid plaque formation (plaque score ≥1.1) (odds ratio 2.43, 95% confidence interval 1.19 to 4.94, p<0.05).
CONCLUSION
Our results suggest that increased levels of ADMA might be involved in the development of carotid atherosclerosis in T2DM.
背景
2 型糖尿病（T2DM）患者的循环不对称二甲基精氨酸（ADMA）浓度升高。
目的
评估 T2DM 患者血浆 ADMA 浓度与颈动脉粥样硬化之间的关系。
受试者和方法
共研究了 72 名新诊断和未经治疗的 T2DM 患者和 72 名健康对照者。通过超声评估内膜-中层厚度（IMT）和斑块评分来确定颈动脉粥样硬化。通过高效液相色谱法测量血浆 ADMA 浓度。
结果
与对照组相比，糖尿病患者的血浆 ADMA、平均 IMT 和斑块评分均较高。单因素和多因素分析表明，ADMA 与糖尿病患者的平均 IMT 之间存在独立关联。在多元逻辑回归分析中，ADMA 是颈动脉斑块形成（斑块评分≥1.1）的唯一预测因子（比值比 2.43，95%置信区间 1.19 至 4.94，p<0.05）。
结论
我们的结果表明，ADMA 水平升高可能与 T2DM 患者颈动脉粥样硬化的发展有关。
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