马查多-约瑟夫病中的睡眠障碍：一项多巴胺转运体成像研究。
Sleep disorders in Machado-Joseph disease: a dopamine transporter imaging study.
机构信息
Department of Neurology, Ataxia Unit, Universidade Federal de São Paulo, São Paulo, Brazil.
出版信息
J Neurol Sci. 2013 Jan 15;324(1-2):90-3. doi: 10.1016/j.jns.2012.10.008. Epub 2012 Nov 6.
OBJECTIVES
Sleep disorders, especially restless legs syndrome (RLS) and rapid eye movement sleep behavior disorder (RBD), are common in spinocerebellar ataxia type 3 or Machado-Joseph disease (MJD), and a possible underlying dopaminergic dysfunction is implicated. This study assessed the relationship between sleep disorders in MJD and dopamine transporter (DAT) densities.
PATIENTS AND METHODS
Twenty-two patients with MJD and twenty healthy subjects were enrolled in this study. MJD patients underwent clinical sleep evaluation and polysomnography. SPECT with [(99m)Tc]-TRODAT-1, was performed in all subjects.
RESULTS
DAT densities were significantly reduced in MJD group when compared to controls. No significant correlation was found between DAT densities and RLS or RBD in MJD.
CONCLUSION
Our study failed to demonstrate a clear correlation between sleep disorders and DAT densities in MJD patients, hence suggesting that extrastriatal and non-presynaptic dopamine pathways could be implicated in MJD-related sleep disorders.
目的
睡眠障碍，尤其是不宁腿综合征（RLS）和快速眼动睡眠行为障碍（RBD），在脊髓小脑共济失调 3 型或 Machado-Joseph 病（MJD）中很常见，这可能与多巴胺能功能障碍有关。本研究评估了 MJD 患者的睡眠障碍与多巴胺转运蛋白（DAT）密度之间的关系。
患者和方法
本研究纳入了 22 名 MJD 患者和 20 名健康受试者。MJD 患者接受了临床睡眠评估和多导睡眠图检查。所有受试者均进行了 [(99m)Tc]-TRODAT-1 SPECT 检查。
结果
与对照组相比，MJD 组的 DAT 密度显著降低。在 MJD 患者中，DAT 密度与 RLS 或 RBD 之间无明显相关性。
结论
本研究未能证明 MJD 患者的睡眠障碍与 DAT 密度之间存在明确的相关性，这表明与 MJD 相关的睡眠障碍可能涉及纹状体外和非突触多巴胺通路。
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