神经肌肉疾病中的骨骼健康及相关代谢并发症
Bone health and associated metabolic complications in neuromuscular diseases.
作者信息
Joyce Nanette C, Hache Lauren P, Clemens Paula R
机构信息
Department of Rehabilitation Medicine, University of California, Davis, Sacramento, CA 95817, USA.
出版信息
Phys Med Rehabil Clin N Am. 2012 Nov;23(4):773-99. doi: 10.1016/j.pmr.2012.08.005. Epub 2012 Oct 17.
Abstract
This article reviews the recent literature regarding bone health as it relates to the patient living with neuromuscular disease (NMD). Studies defining the scope of bone-related disease in NMD are scant. The available evidence is discussed, focusing on abnormal calcium metabolism, increased fracture risk, and the prevalence of both scoliosis and hypovitaminosis D in Duchenne muscular dystrophy, amyotrophic lateral sclerosis, and spinal muscular atrophy. Future directions are discussed, including the urgent need for studies both to determine the nature and extent of poor bone health, and to evaluate the therapeutic effect of available osteoporosis treatments in patients with NMD.
摘要
本文综述了近期有关骨健康与神经肌肉疾病（NMD）患者关系的文献。定义NMD中骨相关疾病范围的研究很少。文中讨论了现有证据，重点关注钙代谢异常、骨折风险增加，以及杜氏肌营养不良症、肌萎缩侧索硬化症和脊髓性肌萎缩症中脊柱侧弯和维生素D缺乏症的患病率。还讨论了未来的方向，包括迫切需要开展研究以确定骨健康不佳的性质和程度，并评估现有骨质疏松症治疗方法对NMD患者的治疗效果。
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