在无锌和锌（II）结合状态下，同二聚体锌传感器AdcR（32 kDa）的主链和立体特异性甲基侧链共振归属。
Backbone and sterospecific methyl side chain resonance assignments of the homodimeric zinc sensor AdcR (32 kDa) in the apo- and Zn(II)-bound states.
作者信息
Guerra Alfredo J, Giedroc David P
机构信息
Department of Chemistry, Indiana University, Bloomington, IN, 47405-7102, USA.
出版信息
Biomol NMR Assign. 2014 Apr;8(1):11-4. doi: 10.1007/s12104-012-9442-6. Epub 2012 Nov 9.
Streptococcus pneumoniae adhesin competence repressor (AdcR) is a Zn(II)-dependent 32 kDa homodimer that controls the transcription of a zinc-specific ABC uptake system (AdcABC), three pneumococcal histidine triad proteins (PhtA, PhtD and PhtE), and an AdcA homolog AdcAII. AdcR is the first metal-dependent member of the MarR family of prokaryotic transcriptional repressors. Two-dimensional NMR studies reveal large changes in the spectrum upon Zn(II) binding. Near complete backbone and stereospecific methyl group resonance assignments for apo- and Zn(II)-AdcR are presented here.
肺炎链球菌黏附素感受态阻遏蛋白（AdcR）是一种依赖锌（II）的32 kDa同型二聚体，它控制着锌特异性ABC摄取系统（AdcABC）、三种肺炎球菌组氨酸三联体蛋白（PhtA、PhtD和PhtE）以及AdcA同源物AdcAII的转录。AdcR是原核转录阻遏蛋白MarR家族中第一个依赖金属的成员。二维核磁共振研究揭示了锌（II）结合后光谱的巨大变化。本文给出了脱辅基和锌（II）-AdcR近乎完整的主链和立体特异性甲基基团共振归属。
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