经显微解剖进行胎儿软组织检查。
Fetal soft tissue examinations by microdissection.
作者信息
Leroy Mariline, Jocteur-Monrozier Audrey
机构信息
Ricerca Biosciences, Saint-Germain sur l'Arbresle, France.
出版信息
Methods Mol Biol. 2013;947:243-53. doi: 10.1007/978-1-62703-131-8_20.
This chapter describes methods for the examination of fetal abdominal and thoracic soft tissues by microdissection on either fresh (non-rodent) or fixed (rodent) specimens in order to detect structural abnormalities. With hundreds of fetuses examined for each species (rodent and non-rodent) in regulatory reproductive toxicity assessments (ICH, http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Multidisciplinary/M3_R2/Step4/M3_R2__Guideline.pdf, 2009; ICH, http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S5_R2/Step4/S5_R2__Guideline.pdf, 2005), microdissection techniques allow a thorough and relatively rapid examination of fetuses for soft tissue abnormalities.
本章介绍了通过对新鲜（非啮齿类）或固定（啮齿类）标本进行显微解剖来检查胎儿腹部和胸部软组织，以检测结构异常的方法。在监管生殖毒性评估中（ICH，http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Multidisciplinary/M3_R2/Step4/M3_R2__Guideline.pdf，2009；ICH，http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S5_R2/Step4/S5_R2__Guideline.pdf，2005），对每种物种（啮齿类和非啮齿类）的数百个胎儿进行了检查，显微解剖技术能够对胎儿进行全面且相对快速的软组织异常检查。
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