Cytopatholgy Division, Tohkai Cytopathology Institute, Cancer Research and Prevention (TCI-CaRP), 5-1-2 Minami-uzura, Gifu City, Gifu 500-8285, Japan.
Curr Drug Targets. 2012 Dec;13(14):1689-97. doi: 10.2174/138945012804545452.
Inflammation is a risk factor for cancer development in several tissues. In the colorectum, inflammatory bowel disease (ulcerative colitis and Crohn's disease) is a longstanding inflammatory disease with increased risk for colorectal cancer (CRC). Several molecular events involving in chronic inflammatory process contribute to multi-stage carcinogenesis of CRC in the inflamed colon. They include alterations in production of reactive oxygen and nitrogen species, upregulation of pro-inflammatory cytokines and inflammatory enzymes, and intestinal immune system. In this short review, experimental animal models of inflammation-associated CRC are described. Also, some preclinical data on chemoprevention of inflammation-associated CRC by astaxanthin and a specific inhibitor of nitric oxide synthase using these inflammation-related CRC models is briefly introduced.
炎症是几种组织中癌症发展的一个风险因素。在结肠直肠，炎症性肠病（溃疡性结肠炎和克罗恩病）是一种长期存在的炎症性疾病，增加了结直肠癌（CRC）的风险。涉及慢性炎症过程的几个分子事件导致炎症结肠中的 CRC 多阶段致癌。它们包括活性氧和氮物种的产生改变、促炎细胞因子和炎症酶的上调以及肠道免疫系统。在这篇简短的综述中，描述了与炎症相关的 CRC 的实验动物模型。此外，还简要介绍了使用这些与炎症相关的 CRC 模型，虾青素和一氧化氮合酶特异性抑制剂对与炎症相关的 CRC 的化学预防的一些临床前数据。
