儿童体内胃饥饿素、营养状况与免疫力之间的关系。
Relation among ghrelin, nutritional status, and immunity in children.
作者信息
Gorczyca Daiva, Basiewicz-Worsztynowicz Barbara, Augustyniak Daria, Karnas-Kalemba Wieslawa, Cebula Hanna, Jankowski Adam
机构信息
Third Department and Clinic of Paediatrics, Immunology and Rheumatology of Developmental Age, Wroclaw Medical University, al. Kasprowicza 64/66, 51-137 Wroclaw, Poland.
出版信息
J Pediatr Endocrinol Metab. 2012;25(7-8):747-52. doi: 10.1515/jpem-2012-0079.
BACKGROUND
Ghrelin is an important mediator of energy balance and metabolism. The aim of this study was to investigate the relationship among ghrelin concentration, growth patterns, and immunological parameters in children with an impairment or inefficiency in functioning of the immune system.
METHODS
Twenty patients with primary immunodeficiency diseases (PIDs), 20 patients with recurrent respiratory tract infections (RRTIs), and 20 healthy children (control group) were included. The anthropometric measurements, ghrelin plasma levels, and selected immunological parameters were measured.
RESULTS
Ghrelin levels and nutritional status parameters (weight, height, and body mass index) values were negatively correlated only in the control group. Ghrelin negatively correlates with complement hemolytic activity in the PID group and with IgA serum level in the RRTI group.
CONCLUSION
Our results show evidence that there is a relationship between ghrelin and nutritional status of healthy children but not in children with PID or RRTI.
背景
胃饥饿素是能量平衡和新陈代谢的重要调节因子。本研究旨在探讨免疫系统功能受损或低效的儿童中胃饥饿素浓度、生长模式和免疫参数之间的关系。
方法
纳入20例原发性免疫缺陷病（PID）患者、20例反复呼吸道感染（RRTI）患者和20名健康儿童（对照组）。测量人体测量指标、血浆胃饥饿素水平和选定的免疫参数。
结果
仅在对照组中，胃饥饿素水平与营养状况参数（体重、身高和体重指数）值呈负相关。在PID组中，胃饥饿素与补体溶血活性呈负相关，在RRTI组中与血清IgA水平呈负相关。
结论
我们的结果表明，胃饥饿素与健康儿童的营养状况之间存在关联，但在PID或RRTI儿童中不存在这种关联。
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