研究方案：重症监护焦虑和情绪恢复（Icare）-一项前瞻性研究。

NHMRC Centre of Research Excellence, Research Centre for Clinical and Community Practice Innovation, Griffith Health Institute, Griffith University, Nathan, Queensland, Australia; School of Nursing and Midwifery, Griffith University, Nathan, Queensland, Australia.

Aust Crit Care. 2013 Aug;26(3):142-7. doi: 10.1016/j.aucc.2012.10.001. Epub 2012 Nov 14.

BACKGROUND

Survivors of intensive care units (ICUs) commonly present with symptoms of anxiety, depression and post-traumatic stress disorder (PTSD) during recovery. A number of factors have been identified as predictors of these adverse emotional outcomes, but the role of state anxiety during critical illness in the development of these emotional problems remains unknown.

PURPOSE

The Intensive Care Anxiety and Emotional Recovery (ICARe) study protocol proposes the development of a statistical model to determine the relationship between state anxiety during ICU stay and symptoms of anxiety, depression and PTSD at three occasions; after ICU discharge but prior to hospital discharge and at the third and sixth months post ICU discharge.

METHODS

Prospective study including adult patients admitted to the ICU of a tertiary metropolitan Australian hospital for ≥24 h who are able to: (1) communicate verbally or nonverbally; (2) understand English and (3) open their eyes spontaneously or in response to voice to respond to the Faces Anxiety Scale (state anxiety assessment). One hundred and seventy patients will be assessed for their levels of state anxiety during their ICU stay to achieve a sample size of about 104 patients six months after discharge. The outcomes of the ICARe study will include symptoms of anxiety, depression and PTSD assessed by standardised questionnaires widely used in intensive care research. Demographic, clinical, and social support information will also be collected.

RESULTS

The projected sample size will provide sufficient power to evaluate the association between state anxiety and adverse emotional outcomes, as well as a variety of variables that will be entered into a multivariate regression analysis.

CONCLUSION

This study will provide new evidence to improve care during critical illness and reduce adverse outcomes during recovery with the potential to decrease unnecessary suffering, promote comfort and improve long-term recovery.

背景

重症监护病房（ICU）的幸存者在康复期间通常会出现焦虑、抑郁和创伤后应激障碍（PTSD）的症状。许多因素已被确定为这些不良情绪结果的预测因素，但在发病期间状态焦虑对这些情绪问题发展的作用仍不清楚。

目的

《重症监护焦虑和情绪恢复（ICARe）研究方案》提出了建立一个统计模型的方法，以确定 ICU 住院期间的状态焦虑与 ICU 出院后、出院前和出院后第三个和第六个月的焦虑、抑郁和 PTSD 症状之间的关系。

方法

这是一项前瞻性研究，纳入了在澳大利亚一家三级大都市医院 ICU 住院时间≥24 小时的成年患者，这些患者能够：（1）口头或非口头交流；（2）理解英语；（3）能够自发睁眼或在听到声音时睁眼，以回答面孔焦虑量表（状态焦虑评估）。将对 170 名患者在 ICU 住院期间的状态焦虑水平进行评估，以达到出院后 6 个月时约 104 名患者的样本量。ICARe 研究的结果将包括使用广泛应用于重症监护研究的标准问卷评估的焦虑、抑郁和 PTSD 症状。还将收集人口统计学、临床和社会支持信息。