Total ankle arthroplasty (TAA) has evolved over time and modern 3-component implants offer good and reliable clinical results. Despite recent improvements, TAA is still associated with a relatively high incidence of complications. Surgeon experience seems to play the most important role. This review highlights the most common intraoperative and postoperative complications, such as malleolar fracture, impingement, cyst formation, malalignment, and loosening, and offers a differentiated concept for their management.