Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Dongcheng, Beijing 100730, China.
J Clin Neurosci. 2013 Feb;20(2):278-80. doi: 10.1016/j.jocn.2012.02.042. Epub 2012 Nov 17.
Although uric acid (UA) concentration has been considered a surrogate marker for monitoring the progression of multiple sclerosis (MS), less is known about the relationship between UA and the progression of neuromyelitis optica (NMO). We therefore investigated the correlations between serum UA concentrations and the clinical and cerebrospinal fluid (CSF) parameters in patients with NMO. Factors assessed in patients with NMO included gender, disease duration, disease disability, CSF white blood cell (WBC) counts, oligoclonal bands (OB), 24 hour immunoglobulin (Ig)G index, and myelin basic protein (MBP) concentration. Mean serum UA concentrations were compared in patients with NMO and in a control group of patients with cerebral infarction (CI). We found that mean serum UA concentrations were significantly lower in patients with NMO compared to those with CI (206.81 compared to 274.00 μmol/L, p=0.00). Serum UA concentration was correlated directly with NMO duration (p=0.013) and was inversely correlated with the Expanded Disability Status Scale score (p=0.021). Patients with NMO with lower serum UA concentrations tended to be positive for OB, to have higher CSF protein and MBP concentrations, and to have higher WBC counts and 24 hour IgG index, but no correlation was statistically significant. UA may be a useful surrogate marker for monitoring NMO activity.
虽然尿酸 (UA) 浓度已被认为是监测多发性硬化症 (MS) 进展的替代标志物,但对于 UA 与视神经脊髓炎 (NMO) 进展之间的关系知之甚少。因此,我们研究了 NMO 患者血清 UA 浓度与临床和脑脊液 (CSF) 参数之间的相关性。评估 NMO 患者的因素包括性别、疾病持续时间、疾病残疾、CSF 白细胞 (WBC) 计数、寡克隆带 (OB)、24 小时免疫球蛋白 (IgG) 指数和髓鞘碱性蛋白 (MBP) 浓度。比较了 NMO 患者和脑梗死 (CI) 患者对照组的平均血清 UA 浓度。我们发现,与 CI 患者相比,NMO 患者的平均血清 UA 浓度明显降低(206.81 与 274.00 μmol/L,p=0.00)。血清 UA 浓度与 NMO 持续时间呈正相关(p=0.013),与扩展残疾状况量表评分呈负相关(p=0.021)。血清 UA 浓度较低的 NMO 患者 OB 阳性的可能性更大,CSF 蛋白和 MBP 浓度更高,WBC 计数和 24 小时 IgG 指数更高,但无统计学相关性。UA 可能是监测 NMO 活动的有用替代标志物。