SUMOylation 沉默小脑颗粒神经元中包含 K2P1 亚基的异二聚体 TASK 钾通道。
SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.
机构信息
Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.
出版信息
Sci Signal. 2012 Nov 20;5(251):ra84. doi: 10.1126/scisignal.2003431.
Abstract
The standing outward K(+) current (IKso) governs the response of cerebellar granule neurons to natural and medicinal stimuli including volatile anesthetics. We showed that SUMOylation silenced half of IKso at the surface of cerebellar granule neurons because the underlying channels were heterodimeric assemblies of K2P1, a subunit subject to SUMOylation, and the TASK (two-P domain, acid-sensitive K(+)) channel subunits K2P3 or K2P9. The heterodimeric channels comprised the acid-sensitive portion of IKso and mediated its response to halothane. We anticipate that SUMOylation also influences sensation and homeostatic mechanisms in mammals through TASK channels formed with K2P1.
摘要
静息外向 K(+) 电流 (IKso) 控制着小脑颗粒神经元对自然和药物刺激的反应，包括挥发性麻醉剂。我们发现 SUMO 化沉默了小脑颗粒神经元表面的 IKso 的一半，因为基础通道是 K2P1 亚基的异二聚体组装，K2P1 是一个可 SUMO 化的亚基，以及 TASK（双 P 域、酸敏感 K(+)）通道亚基 K2P3 或 K2P9。异二聚体通道组成了 IKso 的酸敏感部分，并介导其对氟烷的反应。我们预计，SUMO 化也通过与 K2P1 形成的 TASK 通道影响哺乳动物的感觉和动态平衡机制。
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