Gougoudi E, Zachariou Z, Kogia E, Zavitsanakis A
Pediatric Surgical Department, Medical School, Aristotelian University of Thessaloniki, Greece.
Pediatr Med Chir. 2012 Jul-Aug;34(4):192-7. doi: 10.4081/pmc.2012.73.
The present study investigates the outcome of Fowler-Stephens operation in prepubertal Wistar rats focused on microlithiasis and Leydig cell hyperplasia development.
Thirty-eight (38) animals underwent laparoscopic Fowler-Stephens operation on the right testis (8 of them formed the control group) and 6 of them additional contra-lateral orchectomy. The testes were examined histological 9,30,70 and 90 days later, while ultrasound study was perfomed a day earlier.
Initially, atrophic signs were visible as early as 9 days after the operation. Signs of intratubular calcification were obvious 30 days after the operation, in severe atrophic testes. Another important point was that in the animals that underwent orchectomy, testicular microlithiasis co-existed with lesions of Leydig cell hyperplasia.
Microlithiasis and Leydig cell hyperplasia seem to have causative relation in operated undescended testis and present serious postoperative complications, with a review in the literature.
本研究调查青春期前Wistar大鼠福勒-斯蒂芬斯手术的结果，重点关注微结石症和莱迪希细胞增生的发展。
38只动物接受了右侧睾丸的腹腔镜福勒-斯蒂芬斯手术（其中8只组成对照组），6只额外进行了对侧睾丸切除术。术后9天、30天、70天和90天对睾丸进行组织学检查，而超声检查在检查前一天进行。
最初，术后9天就可见萎缩迹象。术后30天，在严重萎缩的睾丸中，管内钙化迹象明显。另一个重要点是，在接受睾丸切除术的动物中，睾丸微结石症与莱迪希细胞增生病变并存。
微结石症和莱迪希细胞增生在手术治疗的隐睾症中似乎存在因果关系，并存在严重的术后并发症，本文对此进行了文献综述。
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