Dean Charles E
Tardive Dyskinesia Assessment Clinic, Minneapolis Veterans Affairs Health Care Center, One Veterans Drive, Minneapolis, MN 55417, USA.
Perspect Biol Med. 2012 Summer;55(3):443-60. doi: 10.1353/pbm.2012.0028.
During the past five decades, psychiatry has pursued two goals, one being specificity of diagnosis and treatment, and the other a series of all-inclusive diagnostic manuals that paradoxically emphasized the absence of definite boundaries between disorders, and the absence of definite boundaries between disorders and normality (although normality was never defined). Leaders in the field continue to emphasize that diagnoses must be validated by the pathogenesis, course, and response to treatment of specific disorders. However, many current genetic and family studies have failed to support the concept of diagnostic specificity, as has the current use of psychotropic agents, which are now being prescribed with little regard for diagnosis. Although the switch from a categorical diagnostic system to a dimensional system has not been formalized, it seems to have already occurred in practice.
在过去的五十年里,精神病学一直追求两个目标,一个是诊断和治疗的特异性,另一个是一系列包罗万象的诊断手册,而矛盾的是,这些手册强调疾病之间缺乏明确界限,疾病与正常状态之间也缺乏明确界限(尽管正常状态从未被定义)。该领域的领导者继续强调,诊断必须通过特定疾病的发病机制、病程和对治疗的反应来验证。然而,目前许多基因和家族研究未能支持诊断特异性的概念,目前使用精神药物的情况也是如此,现在开这些药时几乎不考虑诊断。虽然从分类诊断系统向维度系统的转变尚未正式确定,但在实践中似乎已经发生了。