Toll 样受体 9 的加工：Toll 样受体 9 激活的关键事件？
Toll-like receptor 9 processing: the key event in Toll-like receptor 9 activation?
机构信息
Institut für Immunologie, Philipps-Universität Marburg, Hans-Meerwein-Str. 2, 35032 Marburg, Germany.
出版信息
Immunol Lett. 2013 Jan;149(1-2):85-7. doi: 10.1016/j.imlet.2012.11.003. Epub 2012 Nov 24.
Toll-like receptor 9 (TLR9) mediated recognition of viral and bacterial DNA activates the innate immune system. Recently proteolytic cleavage of TLR9 in the endosomal/lysosomal compartment by proteases such as cathepsins and asparagine endopeptidase (AEP) has been identified as a key step for TLR9 activation by CpG-DNA. However, mutants of TLR9 that do not affect proteolytic cleavage lost their functionality suggesting a more complex scenario of TLR9 activation.
Toll 样受体 9（TLR9）介导的病毒和细菌 DNA 的识别激活了先天免疫系统。最近，蛋白酶（如组织蛋白酶和天冬酰胺内肽酶（AEP））在内体/溶酶体区室中对 TLR9 的蛋白水解切割已被确定为 CpG-DNA 激活 TLR9 的关键步骤。然而，不影响蛋白水解切割的 TLR9 突变体失去了其功能，这表明 TLR9 激活的情况更为复杂。
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