筛选具有钙通道阻滞活性的植物提取物和植物成分。

Screening of plant extracts and plant constituents for calcium-channel blocking activity.

机构信息

Institut für Pharmazeutische Biologie der Universität München, München, Germany.

出版信息

Phytomedicine. 1997 Mar;4(1):67-71. doi: 10.1016/S0944-7113(97)80030-X.

PMID:23195248

Abstract

Various constituents isolated from plants with described or suggested antihypertensive, spasmolytic or diuretic activity were tested in an in in vitro-guinea pig papillary muscle model for possible calcium-channel blocking activity. Among the isolated compounds some phenylpropanoids of essential oil (e.g. apiol), mono- and sesquiterpene derivatives (e.g. bisabolol-oxide A), naphthoquinones (e.g. juglone, 7-methyljuglone, plumbagin, garlic constituents), some phenolics and alkaloids showed good to moderate activity (IC(50):15-100 μM). Some of the tested compounds caused a prolonged duration of the contraction, suggesting an additional K(+)-channel blocking effect.

摘要

从具有描述或暗示的抗高血压、松弛平滑肌或利尿活性的植物中分离出的各种成分，在体外豚鼠乳头状肌模型中进行了可能的钙通道阻断活性测试。在所分离的化合物中，一些精油中的苯丙素（例如，莪术醇）、单萜和倍半萜衍生物（例如，金合欢醇-氧化物 A）、萘醌（例如，胡桃醌、7-甲基胡桃醌、紫铆因、大蒜成分）、一些酚类和生物碱表现出良好至中等的活性（IC（50）：15-100 μM）。一些测试的化合物导致收缩持续时间延长，提示存在额外的 K（+）通道阻断作用。