Suppr超能文献

雌激素受体α在前列腺发育过程中平滑肌细胞和成纤维细胞中的独特功能。

Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development.

作者信息

Vitkus Spencer, Yeh Chiuan-Ren, Lin Hsiu-Hsia, Hsu Iawen, Yu Jiangzhou, Chen Ming, Yeh Shuyuan

机构信息

Departments of Urology and Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA.

出版信息

Mol Endocrinol. 2013 Jan;27(1):38-49. doi: 10.1210/me.2012-1212. Epub 2012 Nov 30.

Abstract

Estrogen signaling, through estrogen receptor (ER)α, has been shown to cause hypertrophy in the prostate. Our recent report has shown that epithelial ERα knockout (KO) will not affect the normal prostate development or homeostasis. However, it remains unclear whether ERα in different types of stromal cells has distinct roles in prostate development. This study proposed to elucidate how KO of ERα in the stromal smooth muscle or fibroblast cells may interrupt cross talk between prostate stromal and epithelial cells. Smooth muscle ERαKO (smERαKO) mice showed decreased glandular infolding with the proximal area exhibiting a significant decrease. Fibroblast ERαKO mouse prostates did not exhibit this phenotype but showed a decrease in the number of ductal tips. Additionally, the amount of collagen observed in the basement membrane was reduced in smERαKO prostates. Interestingly, these phenotypes were found to be mutually exclusive among smERαKO or fibroblast ERαKO mice. Compound KO of ERα in both fibroblast and smooth muscle showed combined phenotypes from each of the single KO. Further mechanistic studies showed that IGF-I and epidermal growth factor were down-regulated in prostate smooth muscle PS-1 cells lacking ERα. Together, our results indicate the distinct functions of fibroblast vs. smERα in prostate development.

摘要

雌激素信号通过雌激素受体(ER)α已被证明会导致前列腺肥大。我们最近的报告显示,上皮细胞ERα基因敲除(KO)不会影响前列腺的正常发育或内环境稳定。然而,尚不清楚不同类型基质细胞中的ERα在前列腺发育中是否具有不同作用。本研究旨在阐明基质平滑肌或成纤维细胞中ERα基因敲除如何中断前列腺基质细胞与上皮细胞之间的相互作用。平滑肌ERα基因敲除(smERαKO)小鼠的腺体褶皱减少,近端区域显著减少。成纤维细胞ERα基因敲除小鼠的前列腺未表现出这种表型,但导管末端数量减少。此外,smERαKO前列腺基底膜中观察到的胶原蛋白量减少。有趣的是,这些表型在smERαKO或成纤维细胞ERαKO小鼠中是相互排斥的。成纤维细胞和平滑肌中ERα的复合基因敲除显示出每种单基因敲除的综合表型。进一步的机制研究表明,在缺乏ERα的前列腺平滑肌PS-1细胞中,IGF-I和表皮生长因子下调。总之,我们的结果表明成纤维细胞与smERα在前列腺发育中具有不同功能。

相似文献

1
Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development.
Mol Endocrinol. 2013 Jan;27(1):38-49. doi: 10.1210/me.2012-1212. Epub 2012 Nov 30.
2
Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice.
Asian J Androl. 2012 Jul;14(4):546-55. doi: 10.1038/aja.2011.181. Epub 2012 May 21.
5
Altered prostate epithelial development in mice lacking the androgen receptor in stromal fibroblasts.
Prostate. 2012 Mar;72(4):437-49. doi: 10.1002/pros.21445. Epub 2011 Jul 7.

引用本文的文献

2
Combined Effects of Different Endocrine-Disrupting Chemicals (EDCs) on Prostate Gland.
Int J Environ Res Public Health. 2021 Sep 16;18(18):9772. doi: 10.3390/ijerph18189772.
3
Developmental estrogenization: Prostate gland reprogramming leads to increased disease risk with aging.
Differentiation. 2021 Mar-Apr;118:72-81. doi: 10.1016/j.diff.2020.12.001. Epub 2021 Jan 7.
4
Estrogens and development of the rete testis, efferent ductules, epididymis and vas deferens.
Differentiation. 2021 Mar-Apr;118:41-71. doi: 10.1016/j.diff.2020.11.004. Epub 2020 Dec 13.
6
Estrogen in the male: a historical perspective.
Biol Reprod. 2018 Jul 1;99(1):27-44. doi: 10.1093/biolre/ioy043.
7
Estrogens in Male Physiology.
Physiol Rev. 2017 Jul 1;97(3):995-1043. doi: 10.1152/physrev.00018.2016.

本文引用的文献

1
Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice.
Asian J Androl. 2012 Jul;14(4):546-55. doi: 10.1038/aja.2011.181. Epub 2012 May 21.
3
Role for stromal heterogeneity in prostate tumorigenesis.
Cancer Res. 2011 May 15;71(10):3459-70. doi: 10.1158/0008-5472.CAN-10-2999. Epub 2011 Mar 28.
4
Estrogen-initiated transformation of prostate epithelium derived from normal human prostate stem-progenitor cells.
Endocrinology. 2011 Jun;152(6):2150-63. doi: 10.1210/en.2010-1377. Epub 2011 Mar 22.
5
Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis.
Cancer Res. 2011 Feb 15;71(4):1272-81. doi: 10.1158/0008-5472.CAN-10-3142. Epub 2011 Feb 8.
8
Expression of estrogen related proteins in hormone refractory prostate cancer: association with tumor progression.
J Urol. 2010 Nov;184(5):2172-8. doi: 10.1016/j.juro.2010.06.089. Epub 2010 Sep 17.
9
Influence of sex hormones on cancer progression.
J Clin Oncol. 2010 Sep 10;28(26):4038-44. doi: 10.1200/JCO.2009.27.4290. Epub 2010 Jul 19.
10
Antagonism of estrogen-mediated cell proliferation by raloxifene in prevention of ageing-related prostatic hyperplasia.
Asian J Androl. 2010 Sep;12(5):735-43. doi: 10.1038/aja.2010.24. Epub 2010 May 17.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验