供者双胎输血综合征合并低白蛋白血症。

Hypoalbuminemia in donors with twin-twin transfusion syndrome.

机构信息

Division of Neonatology, Willem-Alexander Children's Hospital, Leiden, The Netherlands.

出版信息

Fetal Diagn Ther. 2013;33(2):98-102. doi: 10.1159/000345086. Epub 2012 Nov 29.

DOI:10.1159/000345086

PMID:23208016

Abstract

OBJECTIVE

To estimate the differences in albumin levels between donors and recipients with twin-twin transfusion syndrome (TTTS).

METHODS

We performed a matched case-control study including twin pairs with TTTS treated conservatively (conservative group) or with fetoscopic laser surgery (laser group) and analyzed the albumin levels at birth in donor and recipient twins.

RESULTS

We included 18 twin pairs in the conservative group and 36 control twin pairs (laser group), matched for gestational age at birth. Median albumin levels in donor twins in the conservative group were significantly lower than in recipient twins, 25.0 versus 33.0 g/l, respectively (p = 0.001). In the laser group, albumin levels in donors and recipients were similar, 32.0 versus 32.0 g/l, respectively (p = 0.633). Hypoalbuminemia (albumin level <20 g/l) occurred in 22% (4/18) of donor twins in the conservative group.

CONCLUSIONS

Hypoalbuminemia occurs frequently in donor twins with TTTS treated conservatively. In TTTS treated with laser, donor twins have similar and normal albumin levels compared to recipients, confirming a successfully performed fetoscopic laser procedure.

摘要

目的

评估双胎输血综合征（TTTS）供受者白蛋白水平的差异。

方法

我们进行了一项匹配病例对照研究，纳入了接受保守治疗（保守组）或胎儿镜激光手术治疗（激光组）的 TTTS 双胎，并分析了供受者双胞胎出生时的白蛋白水平。

结果

我们纳入了 18 对接受保守治疗的 TTTS 双胎和 36 对接受激光治疗的对照双胎（激光组），按出生时的胎龄进行匹配。保守组供体双胞胎的中位白蛋白水平明显低于受体双胞胎，分别为 25.0 与 33.0 g/l（p = 0.001）。在激光组中，供体和受体双胞胎的白蛋白水平相似，分别为 32.0 与 32.0 g/l（p = 0.633）。保守组 22%（4/18）的供体双胞胎出现低白蛋白血症（白蛋白水平 <20 g/l）。