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[先天性畸形的患病率问题]

[Problem of the prevalence of congenital malformations].

作者信息

Reznik B Ia, Minkov I P

出版信息

Sov Zdravookhr. 1990(1):41-3.

PMID:2321086
Abstract

Birth-histories and files of 42,275 newborn infants, ambulatory outpatient files of 38,280 children aged between 6 days and 15 years, and also findings of 4,153 autopsies were studied. The study was conducted for the years 1979-87. It was found that on the whole the incidence of congenital malformations (CM) in children 0-15 years old was 2.83 percent, last three years this indicator being 3.27 percent. Among stillborns the proportion of CM was 10.2 percent, among newborns--13.8 per 1,000 and for the last three years it rose up to 18.2. The leading congenital defects in newborn infants, according to prevalence, were malformations of organs of movement, abdominal wall and gastrointestinal tract, malformations of cardiovascular system. The analysis of CM structure among dead children indicated that the most prevalent were malformations of the central nervous system and also two last above-mentioned groups. The majority of children with CM among the dead were children of the first year of life. Proceeding from these findings the principal ways of CM prevention were suggested and main risk groups with regard to birth defects were identified.

摘要

研究了42275例新生儿的出生史和档案、38280例6天至15岁儿童的门诊病历以及4153例尸检结果。该研究在1979年至1987年期间进行。结果发现,总体而言,0至15岁儿童先天性畸形(CM)的发生率为2.83%,最近三年这一指标为3.27%。死产儿中CM的比例为10.2%,新生儿中为每1000例中有13.8例,最近三年上升至18.2例。根据患病率,新生儿中主要的先天性缺陷是运动器官、腹壁和胃肠道畸形、心血管系统畸形。对死亡儿童中CM结构的分析表明,最常见的是中枢神经系统畸形以及上述最后两组。死亡儿童中患有CM的大多数是一岁以内的儿童。根据这些发现,提出了CM预防的主要方法,并确定了出生缺陷的主要风险群体。

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