Exercise and Health Laboratory, Interdisciplinary Centre for the Study of Human Performance, Faculty of Human Kinetics, Technical University of Lisbon, Cruz-Quebrada, Portugal.
Transplantation. 2013 Jan 27;95(2):372-7. doi: 10.1097/TP.0b013e31827220e7.
Liver transplantation is nowadays the only effective answer to adjourn the outcome of functional limitations associated with familial amyloidotic polyneuropathy (FAP), a neurodegenerative disease characterized by sensory and motor polyneuropathies. Nevertheless, there is a detrimental impact associated with the after-surgery period on the fragile physical condition of these patients. Exercise training has been proven to be effective on reconditioning patients after transplantation. However, the effects of exercise training in liver transplanted FAP patients have not been scrutinized yet.
The study aimed to evaluate the effects of a 24-week exercise training program (supervised or home-based) on body composition, muscle strength, and walking capacity of liver transplanted FAP patients. To fulfill this goal, a sample corresponding to 33% of all FAP patients who undergone a liver transplantation in the area of Lisbon between January 2006 and December 2008 were followed over time. Three evaluation periods were accomplished: M1 (pre-exercise training period), M2 (immediate post-exercise training period), and M3 (24 weeks after M2). The former allowed an assessment of the impact of detraining in these patients.
The exercise training program improved body composition (lean mass and total body skeletal muscle mass), weight, and walking capacity. The improvements were more pronounced within the patients with supervised exercise training compared with the patients on the home-based program. In general, the benefits of the exercise training perdure even after a 24-week detraining period.
Exercise training results in significant improvements on the physical condition of liver transplanted FAP patients.
肝移植是现今唯一有效的方法，可以延缓与家族性淀粉样多神经病（FAP）相关的功能限制的结果，这是一种以感觉和运动多神经病为特征的神经退行性疾病。然而，手术后期间对这些患者脆弱的身体状况会产生不利影响。运动训练已被证明对移植后患者的康复有效。然而，运动训练对肝移植 FAP 患者的影响尚未得到仔细研究。
本研究旨在评估为期 24 周的运动训练计划（监督或家庭为基础）对肝移植 FAP 患者的身体成分、肌肉力量和步行能力的影响。为了实现这一目标，对 2006 年 1 月至 2008 年 12 月期间在里斯本地区接受肝移植的所有 FAP 患者的 33%进行了随访。完成了三个评估期：M1（运动训练前）、M2（运动训练即刻后）和 M3（M2 后 24 周）。前者允许评估这些患者停训的影响。
运动训练计划改善了身体成分（瘦体重和全身骨骼肌质量）、体重和步行能力。监督运动训练的患者比家庭运动训练的患者的改善更为明显。一般来说，运动训练的益处甚至在 24 周的停训期后仍然存在。
运动训练可显著改善肝移植 FAP 患者的身体状况。
