Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Virology. 2013 Jan 5;435(1):157-69. doi: 10.1016/j.virol.2012.09.012.
Viral infections cause an immunological disequilibrium that provokes CD8 T cell responses. These cells play critical roles in purging acute infections, limiting persistent infections, and conferring life-long protective immunity. At every stage of the response anti-viral CD8 T cells are sensitive to signals from cytokines. Initially cytokines operate as immunological warning signs that inform of the presence of an infection, and also influence the developmental choices of the responding cells. Later during the course of the response other sets of cytokines support the survival and maintenance of the differentiated anti-viral CD8 T cells. Although many cytokines promote virus-specific CD8 T cells, other cytokines can suppress their activities and thus favor viral persistence. In this review we discuss how select cytokines act to regulate anti-viral CD8 T cells throughout the response and influence the outcome of viral infections.
病毒感染会导致免疫失衡，从而引发 CD8 T 细胞应答。这些细胞在清除急性感染、限制持续性感染和提供终身保护免疫方面发挥着关键作用。在抗病毒 CD8 T 细胞反应的每个阶段，细胞因子信号都很敏感。最初，细胞因子作为免疫警示信号，提示感染的存在，并影响反应细胞的发育选择。在反应过程的后期，其他细胞因子集支持分化的抗病毒 CD8 T 细胞的存活和维持。虽然许多细胞因子促进病毒特异性 CD8 T 细胞，但其他细胞因子可以抑制它们的活性，从而有利于病毒的持续存在。在这篇综述中，我们讨论了选择细胞因子如何在整个反应过程中调节抗病毒 CD8 T 细胞，并影响病毒感染的结果。
