Takano S, Oishi T, Watanabe Y, Higaki T, Moriguchi M, Oishi H, Seki N, Fujii M, Tanaka T
Third Dept. of Surgery, Nihon University School of Medicine.
Gan To Kagaku Ryoho. 1990 Apr;17(4 Pt 1):675-9.
A total of 30 pieces of Kyosera Injection Port, as a kind of implantable reservoir, was used in 29 cases of liver tumor for an intermittent repeated chemotherapy. Of these 27 cases were actually used between Aug. 1st, 1986 and Aug. 31st, 1989. In this paper we studied the safety of the reservoir. The observation period averaged 259.4 days, with the highest of 760 days and the lowest of 29 days. The injection times averaged 12.7 times, with the maximum of 40 times and the minimum of one. The reservoir was placed under the laparotomy, and the cases which underwent cholecystectomy were 93.1%. 16 cases were treated with intraarterial infusion, and 14 with intraportal infusion. We investigated the complication of Kyosera Injection Port in 27 cases. As a result, there were no complication such as catheter occlusion and infection via catheter. But of 27 cases, 8 cases were recognized a complication, and the rate was 29.6%. Lumbago was noted during infusion chemotherapy in three cases, and on the other hand, there were steatolysis and necrosis of the tissue surrounding the implantation site, a movement of port, a catheter out of vessel, a leakage of the drug, and intraabdominal bleeding after taking off the catheter. But of 8 complication cases, only two cases were not able to inject drug. As a result, the rate of complication was 70.4% in over all. On the other hand, of 27 cases, there were 5 cases which recognized the complication caused by reservoir in itself. The safety rate was 81.5%. In such a circumstance this reservoir was very safe and seemed suitable to the implantable reservoir.
总共使用了30个京赛拉注射端口，作为一种可植入式储液器，用于29例肝肿瘤患者的间歇性重复化疗。其中27例在1986年8月1日至1989年8月31日期间实际使用。本文研究了该储液器的安全性。观察期平均为259.4天，最长760天，最短29天。注射次数平均为12.7次，最多40次，最少1次。储液器通过剖腹术放置，接受胆囊切除术的病例占93.1%。16例采用动脉内灌注治疗，14例采用门静脉内灌注治疗。我们调查了27例患者中京赛拉注射端口的并发症。结果，未出现诸如导管堵塞和经导管感染等并发症。但在27例患者中，有8例出现并发症，发生率为29.6%。3例在灌注化疗期间出现腰痛，另一方面，出现了植入部位周围组织的脂肪溶解和坏死、端口移位、导管脱出血管、药物渗漏以及拔管后腹腔内出血。但在8例并发症病例中，只有2例无法注射药物。结果，总体并发症发生率为70.4%。另一方面，在27例患者中，有5例出现了由储液器本身引起的并发症。安全率为81.5%。在这种情况下，这种储液器非常安全，似乎适合作为可植入式储液器。
