Schwarz Eva C, Qu Bin, Hoth Markus
Department of Biophysics, Saarland University, Homburg, Germany.
Biochim Biophys Acta. 2013 Jul;1833(7):1603-11. doi: 10.1016/j.bbamcr.2012.11.016. Epub 2012 Dec 3.
Killing cancer cells by cytotoxic T lymphocytes (CTL) and by natural killer (NK) cells is of vital importance. Cancer cell proliferation and apoptosis depend on the intracellular Ca(2+) concentration, and the expression of numerous ion channels with the ability to control intracellular Ca(2+) concentrations has been correlated with cancer. A rise of intracellular Ca(2+) concentrations is also required for efficient CTL and NK cell function and thus for killing their targets, in this case cancer cells. Here, we review the data on Ca(2+)-dependent killing of cancer cells by CTL and NK cells. In addition, we discuss emerging ideas and present a model how Ca(2+) may be used by CTL and NK cells to optimize their cancer cell killing efficiency. This article is part of a Special Issue entitled: 12th European Symposium on Calcium.
细胞毒性T淋巴细胞（CTL）和自然杀伤（NK）细胞杀死癌细胞至关重要。癌细胞的增殖和凋亡取决于细胞内Ca(2+)浓度，并且许多能够控制细胞内Ca(2+)浓度的离子通道的表达已与癌症相关联。细胞内Ca(2+)浓度的升高对于有效的CTL和NK细胞功能也是必需的，因此对于杀死它们的靶标（在这种情况下为癌细胞）也是必需的。在这里，我们综述了关于CTL和NK细胞对癌细胞进行Ca(2+)依赖性杀伤的数据。此外，我们讨论了新出现的观点，并提出了一个模型，说明CTL和NK细胞如何利用Ca(2+)来优化其癌细胞杀伤效率。本文是名为“第12届欧洲钙研讨会”的特刊的一部分。
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