丙型肝炎基因1型嵌合疫苗在小鼠中具有免疫原性，且比天然毒株诱导更强的T细胞反应。
Hepatitis C genotype 1 mosaic vaccines are immunogenic in mice and induce stronger T-cell responses than natural strains.
作者信息
Yusim Karina, Dilan Rebecca, Borducchi Erica, Stanley Kelly, Giorgi Elena, Fischer William, Theiler James, Marcotrigiano Joseph, Korber Bette, Barouch Dan H
机构信息
Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
出版信息
Clin Vaccine Immunol. 2013 Feb;20(2):302-5. doi: 10.1128/CVI.00605-12. Epub 2012 Dec 5.
Abstract
Despite improved hepatitis C virus (HCV) treatments, vaccines remain an effective and economic option for curtailing the epidemic. Mosaic protein HCV genotype 1 vaccine candidates designed to address HCV diversity were immunogenic in mice. They elicited stronger T-cell responses to NS3-NS4a and E1-E2 proteins than did natural strains, as assessed with vaccine-matched peptides.
摘要
尽管丙型肝炎病毒（HCV）治疗方法有所改进，但疫苗仍是控制该流行病的一种有效且经济的选择。旨在应对HCV多样性而设计的镶嵌蛋白HCV 1型候选疫苗在小鼠中具有免疫原性。与天然毒株相比，它们对NS3-NS4a和E1-E2蛋白引发了更强的T细胞反应，这是通过与疫苗匹配的肽进行评估的。
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