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2007-2009 年多哥和布基纳法索脑膜炎病例中肺炎球菌血清型分布。

Pneumococcal serotype distribution among meningitis cases from Togo and Burkina Faso during 2007-2009.

机构信息

Agence de Medecine Preventive, Paris, France.

出版信息

Vaccine. 2012 Dec 31;30 Suppl 6:G41-5. doi: 10.1016/j.vaccine.2012.10.052.

Abstract

We evaluated pneumococcal serotype/group distribution using polymerase chain reaction (PCR) testing on cerebrospinal fluid collected from patients from Burkina Faso and Togo who presented for care during 2007-2009. We identified 282 pneumococcal meningitis cases based on PCR, latex agglutination, or culture, of which 206 underwent serotyping. Serotype 1 was identified for 18% of serotyped cases from patients aged <5 years and 66% of those aged ≥5 years. The 13-valent and 10-valent pneumococcal conjugate vaccines (PCV-13 and PCV-10) contain 53% of serotypes identified among children age <5 years and 76-77% among persons aged ≥5 years. Pneumococcal meningitis was highly seasonal regardless of serotype. Data from this study emphasize the potential usefulness of PCVs among older children and adults.

摘要

我们使用聚合酶链反应(PCR)检测了来自布基纳法索和多哥的在 2007 年至 2009 年期间因疾病就诊的患者的脑脊液中的肺炎球菌血清型/组分布情况。我们根据 PCR、乳胶凝集或培养鉴定了 282 例肺炎球菌性脑膜炎病例,其中 206 例进行了血清分型。18%的<5 岁血清型病例和 66%的≥5 岁血清型病例为血清型 1。13 价和 10 价肺炎球菌结合疫苗(PCV-13 和 PCV-10)包含了 53%的<5 岁儿童血清型和 76-77%的≥5 岁儿童血清型。肺炎球菌性脑膜炎的发生具有很强的季节性,与血清型无关。本研究的数据强调了 PCV 在较大儿童和成人中的潜在用途。

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