一种用于L-二羟基苯丙氨酸的新型硼酸基荧光传感器。
A new boronic acid-based fluorescent sensor for L-dihydroxyphenylalanine.
作者信息
Wu Z Y, Yang X Y, Xu W F, Wang B H, Fang H
机构信息
Department of Medicinal Chemistry, Shandong University, Ji'nan, China.
出版信息
Drug Discov Ther. 2012 Oct;6(5):238-41.
PMID:23229143
Abstract
Catecholamines, such as dopamine and L-dihydroxyphenylalanine (L-DOPA), are associated with different physiological functions and diseases. In our recent studies, a novel water-soluble boronic acid compound 3c was identified as a selective fluorescent sensor for L-DOPA. This compound not only has the ability to interact with dopamine and catechol, but also has no fluorescence intensity change for L-DOPA precursors in vivo, such as L-tyrosine.
摘要
儿茶酚胺类物质，如多巴胺和L-二羟基苯丙氨酸（L-DOPA），与不同的生理功能和疾病相关。在我们最近的研究中，一种新型水溶性硼酸化合物3c被鉴定为L-DOPA的选择性荧光传感器。该化合物不仅能够与多巴胺和儿茶酚相互作用，而且对体内L-DOPA的前体，如L-酪氨酸，没有荧光强度变化。
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