Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Mol Neurobiol. 2013 Feb;47(1):435-42. doi: 10.1007/s12035-012-8381-7. Epub 2012 Dec 11.
Developmental dyslexia (DD) is a highly heritable neurological disorder that is prevalent in school-aged children. The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. However, the associations between DCDC2 genetic variations and dyslexia have yielded inconclusive results. Clarifying the effects of DCDC2 polymorphisms on dyslexia risk will advance not only elucidation of the role of DCDC2 in the brain development but also development of possible therapeutic approach for dyslexia. In this review, we summarized the ongoing association studies concerning DCDC2 polymorphisms and dyslexia risk by using meta-analysis and revealed that DCDC2 rs807701 might contribute significantly to dyslexia risk.
发展性阅读障碍（DD）是一种高度遗传性的神经紊乱疾病，在学龄儿童中很常见。与阅读障碍相关的基因 DCDC2 是 DCX 家族基因的成员，已知其在神经发生、神经元迁移和分化中发挥作用。然而，DCDC2 基因变异与阅读障碍之间的关联尚未得出明确的结果。阐明 DCDC2 多态性对阅读障碍风险的影响不仅将有助于阐明 DCDC2 在大脑发育中的作用，而且还将为阅读障碍的可能治疗方法的开发提供依据。在这篇综述中，我们通过荟萃分析总结了关于 DCDC2 多态性与阅读障碍风险的关联研究，并表明 DCDC2 rs807701 可能显著增加阅读障碍的风险。
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