Neuromuscular Clinic, Departments of Neurology and Neurophysiology, University Hospitals of Leicester, Leicester, UK.
J Neurol Sci. 2013 Feb 15;325(1-2):36-8. doi: 10.1016/j.jns.2012.11.010. Epub 2012 Dec 11.
Few studies have evaluated the functional and electrophysiological correlates of hand-held grip dynamometry in neuromuscular disease. The practical value of normative values remains uncertain in clinical practice. We aimed to ascertain the value, clinical and electrophysiological correlates, as well as utility of normative values for grip dynamometry, in a cohort of subjects with chronic inflammatory demyelinating polyneuropathy (CIDP).
We performed a cross-sectional study of 31 prospectively recruited subjects with CIDP, using Jamar hand-held grip dynamometry, conventional clinical assessments and electrophysiology.
Grip dynamometry correlated highly with motor, sensory and functional scores in the upper limbs as well as with global function. There were significant correlations with summated median/ulnar, and ulnar compound muscle action potentials. Patients' readings were significantly lower than median normative values but comparable to fifth percentile normative figures.
Jamar grip dynamometry is a reliable measure of global neurological status in patients with CIDP, not limited to upper limb or exclusively motor function. At optimum level of function, CIDP patients had comparable dynamometry recordings to fifth percentile normative values, which may represent a realistic aim for treated subjects with the disorder, with currently available therapies.
很少有研究评估手持式握力测力计在神经肌肉疾病中的功能和电生理相关性。在临床实践中，规范值的实际价值仍然不确定。我们旨在确定在慢性炎症性脱髓鞘性多发性神经病（CIDP）患者队列中，握力测力计的规范值的价值、临床和电生理相关性以及实用性。
我们对 31 名前瞻性招募的 CIDP 患者进行了横断面研究，使用 Jamar 手持式握力测力计、常规临床评估和电生理学。
握力测力计与上肢的运动、感觉和功能评分以及整体功能高度相关。与总和正中/尺神经、尺神经复合肌肉动作电位也有显著相关性。患者的读数明显低于中位数规范值，但与第五百分位规范数值相当。
Jamar 握力测力计是 CIDP 患者整体神经状态的可靠测量指标，不仅限于上肢或仅用于运动功能。在最佳功能水平下，CIDP 患者的握力测力计记录与第五百分位规范值相当，这可能代表了目前可用治疗方法治疗的该疾病患者的现实目标。
