两种不同脂肪乳剂全胃肠外营养对兔脑脂质组成的影响

Brain lipid composition in rabbits after total parenteral nutrition with two different lipid emulsions.

机构信息

Internal Medicine Service, Hospital Perpetuo Socorro, Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain.

出版信息

Nutrition. 2013 Jan;29(1):313-7. doi: 10.1016/j.nut.2012.07.020.

DOI:10.1016/j.nut.2012.07.020

PMID:23237652

Abstract

OBJECTIVE

To study the changes occurring in brain lipid composition after the administration of total parenteral nutrition (TPN) by comparing two lipid emulsions, one with long-chain triacylglycerols (LCT) and the other with long-chain and medium-chain triacylglycerols (MCT/LCT 50%/50%).

METHODS

We used 21 young New Zealand rabbits divided into three groups of seven animals each. Two groups were subjected to TPN for 7 d, with each group receiving using one of two different lipid emulsions: Intralipid 20% (group LCT) and Lipofundin MCT/LCT 20% (group MCT/LCT). The third control group received an oral diet and underwent the same surgical procedure with the administration of intravenous saline solution. The energy administered in the TPN formulas was non-protein 100 kcal ∙ kg(-1) ∙ d(-1), with 40% corresponding to fats.

RESULTS

There were modest increases in plasma cholesterol and triacylglycerols. In the brain tissue, there was a decrease of phosphatidylcholine in animals with TPN, which was greater in group LCT. There were no significant differences in the overall percentage distribution of brain fatty acids among the groups.

CONCLUSION

The lipid emulsions administered in TPN, especially those prepared exclusively with LCT, cause changes in the brain lipid polar fractions of young rabbits.

摘要

目的

通过比较两种脂肪乳剂（一种含长链三酰甘油（LCT），另一种含长链和中链三酰甘油（MCT/LCT 50%/50%），研究全肠外营养（TPN）给药后脑脂质组成的变化。

方法

我们使用 21 只年轻的新西兰兔，分为三组，每组 7 只。两组给予 TPN 7 天，每组使用两种不同的脂肪乳剂之一：20%Intralipid（LCT 组）和 20%Lipofundin MCT/LCT（MCT/LCT 组）。第三组对照组给予口服饮食，并接受相同的手术程序，给予静脉生理盐水。TPN 配方中的非蛋白能量为 100 kcal·kg（-1）·d（-1），其中 40%为脂肪。