A combined sensitivity for frequency and interaural intensity difference in neurons in the auditory midbrain of the grassfrog.

The relation between spectral tuning and sensitivity for interaural intensity difference (IID) was studied for single units in the auditory midbrain of the grassfrog. The stimuli consisted of sequences of pure tones of different frequency and interaural intensity differences presented by means of a closed sound system. At best excitatory frequency, three types of binaural interaction were observed: E0 (one ear excitatory 23%), EE (both ears excitatory 9%) and EI (one ear excitatory, the other inhibitory 67%). For a considerable number of units different types of binaural interaction were observed for different stimulus frequencies. More than 30% of the binaural units had multiple excitatory and inhibitory regions in their spectrotemporal selectivity. E0 and EI units had uniformly distributed best frequencies, EE units generally had best frequencies near 1.0 kHz. The E0 and EE categories had response latencies less than about 70 ms whereas EI units could have longer latencies. Most EE and all EI category units had sigmoidally shaped IID-rate curves. About 40% of the units had a combined sensitivity for sound spectrum and IID which was invariant to overall stimulus intensity. For nearly all EI units the inhibitory influence of the ipsilateral ear was confined to frequencies in the 0.4-1.6 kHz range and was not correlated with a unit's best frequency. By means of a simple additive model we demonstrated that determination of sound source laterality can be achieved by ensemble coding in the auditory midbrain.