Tsuchitani M, Kuroda J, Nagatani M, Miura K, Katoh T, Saegusa T, Narama I, Itakura C
Mitsubishi-Kasei Institute of Toxicological and Environmental Sciences, Ibaraki, Japan.
J Comp Pathol. 1990 Feb;102(2):179-90. doi: 10.1016/s0021-9975(08)80123-5.
Cytoplasmic and nuclear accumulation of glycogen granules in the kidney cells of 72 male WBN/Kob rats with a long-term diabetic condition was studied histologically and by electron microscopy. The incidence and degree of the accumulation showed good correlation with the blood glucose concentration. In the kidneys, there was evidence of two types of lesion, cytoplasmic glycogen accumulation in the distal convoluted tubules and nuclear accumulation in the ascending thick segment of Henle's loops. Electron microscopically, the cytoplasmic glycogen accumulation was often associated with an increased number of lysosomal bodies containing lamellar bodies. Glycogen bodies, the halo of which was thought to be identical with that of nuclear bodies, were frequently observed in the nuclei containing the glycogen granules. These morphological and topographical differences between the two types of lesion were considered suggestive of different pathogenetic mechanisms for glycogen accumulation in the kidney cells.
对72只患有长期糖尿病的雄性WBN/Kob大鼠肾细胞中糖原颗粒的细胞质和细胞核积累情况进行了组织学和电子显微镜研究。积累的发生率和程度与血糖浓度呈现出良好的相关性。在肾脏中，有两种病变的证据，即远曲小管中的细胞质糖原积累和亨氏袢升支粗段中的细胞核积累。电子显微镜下，细胞质糖原积累常与含有板层小体的溶酶体数量增加有关。在含有糖原颗粒的细胞核中经常观察到糖原小体，其晕圈被认为与核小体的晕圈相同。这两种病变在形态和位置上的差异被认为提示肾细胞中糖原积累的发病机制不同。
