单纯疱疹病毒脑炎:通往大脑的免费通道。

Herpes simplex virus encephalitis: toll-free access to the brain.

机构信息

Geisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, One Medical Center Drive, Lebanon, NH 03756, USA.

出版信息

Cell Host Microbe. 2012 Dec 13;12(6):731-2. doi: 10.1016/j.chom.2012.11.005.

Abstract

Herpes simplex encephalitis (HSE) is a devastating infection of the central nervous system (CNS). Lafaille et al. (2012) show that susceptibility to HSE is due to mutations in Toll-like receptor response pathways that directly reduce the intrinsic resistance of neurons and other cells in the CNS to HSV infection.

摘要

单纯疱疹病毒性脑炎(HSE)是一种中枢神经系统(CNS)的破坏性感染。Lafaille 等人。(2012)表明,HSE 的易感性是由于 Toll 样受体反应途径的突变,这些突变直接降低了神经元和 CNS 中其他细胞对 HSV 感染的固有抵抗力。

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