PACAP 在性腺水平对女性生育和生殖的作用——最新进展。
Role of PACAP in Female Fertility and Reproduction at Gonadal Level - Recent Advances.
机构信息
Department of Anatomy, Lendulet PACAP-Research Team of the University of Pécs and Hungarian Academy of Sciences Pécs, Hungary.
出版信息
Front Endocrinol (Lausanne). 2012 Dec 11;3:155. doi: 10.3389/fendo.2012.00155. eCollection 2012.
Abstract
Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide, first isolated from hypothalamic extracts, but later shown in peripheral organs, such as endocrine glands, gastrointestinal system, cardiovascular system, and reproductive organs. PACAP plays a role in fertility and reproduction. Numerous studies report on the gonadal regulatory effects of PACAP at hypothalamo-hypophyseal levels. However, the local effects of PACAP at gonadal levels are also important. The present review summarizes the effects of PACAP in the ovary. PACAP and its receptors are present in the ovary, and PACAP plays a role in germ cell migration, meiotic division, follicular development, and atresia. The autocrine-paracrine hormonal effects seem to play a regulatory role in ovulation, luteinization, and follicular atrophy. Altogether, PACAP belongs to the ovarian regulatory peptides.
摘要
垂体腺苷酸环化酶激活肽（PACAP）是一种多功能神经肽，最初从下丘脑提取物中分离出来，但后来在周围器官如内分泌腺、胃肠道系统、心血管系统和生殖器官中显示出来。PACAP 在生育和生殖中发挥作用。许多研究报告了 PACAP 在下丘脑-垂体水平对性腺的调节作用。然而，PACAP 在性腺水平的局部作用也很重要。本综述总结了 PACAP 在卵巢中的作用。PACAP 及其受体存在于卵巢中，PACAP 在生殖细胞迁移、减数分裂、卵泡发育和闭锁中发挥作用。自分泌-旁分泌激素作用似乎在排卵、黄体化和卵泡萎缩中起调节作用。总的来说，PACAP 属于卵巢调节肽。
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