Guièze Romain, Ysebaert Loïc, de Guibert Sophie, Dhédin Nathalie, Bay Jacques-Oliver, Troussard Xavier, Tournilhac Olivier
Inserm CIC-501, EA7283, CHU Estaing, université d'Auvergne, service d'hématologie clinique adultes et de thérapie cellulaire, 1, place Lucie-Aubrac, 63000 Clermont-Ferrand, France.
Bull Cancer. 2012 Dec;99(12):1123-32. doi: 10.1684/bdc.2012.1673.
The choice of salvage therapy for patients presenting relapsed chronic lymphocytic leukemia (CLL) has to take into account some factors influencing tumor resistance and comorbidities. Since 2010, new drugs targeting the tumor cells' signaling have been proposed for CLL patients. Waiting the results of various clinical trials evaluating these treatments, there is a need to describe the state-of-the-art concerning approved treatments such as chemotherapy and monoclonal antibodies.
对于复发的慢性淋巴细胞白血病(CLL)患者,挽救治疗方案的选择必须考虑一些影响肿瘤耐药性和合并症的因素。自2010年以来,针对CLL患者提出了靶向肿瘤细胞信号传导的新药。在等待评估这些治疗方法的各种临床试验结果期间,有必要描述一下诸如化疗和单克隆抗体等已获批治疗方法的最新情况。