S. 伯特·沃尔巴赫、落矶山斑点热和吸血节肢动物：早期调查病理学家的胜利。

S. Burt Wolbach, Rocky Mountain spotted fever, and blood-sucking arthropods: triumph of an early investigative pathologist.

机构信息

Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Texas 77030, USA.

出版信息

Am J Pathol. 2013 Feb;182(2):291-3. doi: 10.1016/j.ajpath.2012.11.011. Epub 2012 Dec 17.

DOI:10.1016/j.ajpath.2012.11.011

PMID:23256917

Abstract

In a series of four articles published between 1916 and 1919 in The Journal of Medical Research, precursor to The American Journal of Pathology, the investigative pathologist S. Burt Wolbach unambiguously showed that Rocky Mountain spotted fever has a tick-borne mode of transmission, the causative agent replicates intracellularly, and the disease is fundamentally a vasculitis. Although underappreciated, Wolbach's tour-de-force work epitomized investigative pathology. These four articles should be mandatory reading for young investigators and are recommended also to seasoned investigators who seek reinvigoration in the beauty in their craft.

摘要

在 1916 年至 1919 年期间，先驱期刊《美国病理学杂志》（The American Journal of Pathology）的前身《医学研究杂志》（The Journal of Medical Research）连续发表了四篇文章，其中调查病理学家 S. 伯特·沃尔巴赫（S. Burt Wolbach）明确表明落基山斑疹热具有蜱媒传播方式，病原体在细胞内复制，该疾病从根本上说是一种血管炎。尽管沃尔巴赫的这项杰出工作未得到充分重视，但它堪称调查病理学的典范。这四篇文章应该成为年轻研究者的必读书目，也推荐给那些希望在自己的专业领域中重拾活力的资深研究者阅读。