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颅内硬脑膜动静脉瘘患者管理的立体定向放射外科治疗指南

Stereotactic radiosurgery guidelines for the management of patients with intracranial dural arteriovenous fistulas.

作者信息

Niranjan Ajay, Lunsford L Dade

机构信息

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.

出版信息

Prog Neurol Surg. 2013;27:218-26. doi: 10.1159/000341799. Epub 2012 Dec 11.

Abstract

Treatment options for dural arteriovenous fistulas (DAVFs) have expanded with the application of stereotactic radiosurgery (SRS). Our objective was to provide guidelines about the use of SRS in symptomatic patients with imaging-identified DAVFs of the brain. The authors reviewed evidence-based medicine and clinical experience with radiosurgery for DAVFs of the brain and developed guidelines and provided a scientific foundation for patients and physicians. Major recommendations include the definition of DAVF patients suitable for various management strategies ranging from observation to surgical excision to endovascular embolization and SRS. Combined SRS and embolization is an effective management strategy for DAVFs, including those that have recurred after initial embolization. The effect of prior embolization has been evaluated. SRS before embolization facilitates the better recognition of the entire target. For selected DAVF patients who are not eligible for embolization or surgery, SRS alone is an effective treatment option. The dose range for DAVFs is similar to that of arteriovenous malformations. A clinical algorithm for the potential role of SRS for a symptomatic brain DAVF was defined. These guidelines provide a framework for professional judgment and treatment selection alternatives for the management of DAVFs.

摘要

随着立体定向放射外科(SRS)的应用,硬脑膜动静脉瘘(DAVF)的治疗选择有所增加。我们的目标是为影像学确诊的有症状脑DAVF患者使用SRS提供指导原则。作者回顾了关于脑DAVF放射外科的循证医学和临床经验,制定了指导原则,并为患者和医生提供了科学依据。主要建议包括明确适合从观察到手术切除、血管内栓塞及SRS等各种治疗策略的DAVF患者。SRS联合栓塞是治疗DAVF的有效策略,包括那些在初次栓塞后复发的患者。已评估了先前栓塞的效果。栓塞前进行SRS有助于更好地识别整个靶区。对于不适合栓塞或手术的特定DAVF患者,单纯SRS是一种有效的治疗选择。DAVF的剂量范围与动静脉畸形相似。定义了SRS对有症状脑DAVF潜在作用的临床算法。这些指导原则为DAVF治疗的专业判断和治疗选择提供了框架。

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