活动性猿分枝杆菌肺部感染患者肺移植的首例报告。

First report of lung transplantation in a patient with active pulmonary Mycobacterium simiae infection.

作者信息

Qvist T, Katzenstein T L, Lillebaek T, Iversen M, Mared L, Andersen A B

机构信息

Copenhagen CF Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

出版信息

Transplant Proc. 2013 Mar;45(2):803-5. doi: 10.1016/j.transproceed.2012.02.034. Epub 2012 Sep 6.

DOI:10.1016/j.transproceed.2012.02.034

PMID:23267789

Abstract

Mycobacterium simiae is a slow-growing mycobacteria that in rare cases can cause chronic pulmonary infection. We report the first case of lung transplantation in a patient with active M simiae infection at the time of transplantation. A 56-year-old immunocompetent nonsmoking woman underwent bilateral lung transplantation for end-stage idiopathic bronchiectasis and chronic M simiae infection. The disease proved manageable on a regimen of clarithromycin, moxifloxacin, and cotrimoxazole with a successful outcome 1-year posttransplantation. There is increasing evidence that nontuberculous mycobacterium infection should no longer be an absolute contraindication for lung transplantation.

摘要

西氏分枝杆菌是一种生长缓慢的分枝杆菌，在罕见情况下可引起慢性肺部感染。我们报告了首例在移植时患有活动性西氏分枝杆菌感染的患者接受肺移植的病例。一名56岁免疫功能正常的不吸烟女性因终末期特发性支气管扩张症和慢性西氏分枝杆菌感染接受了双侧肺移植。事实证明，在克拉霉素、莫西沙星和复方新诺明的治疗方案下，病情是可控的，移植后1年取得了成功的结果。越来越多的证据表明，非结核分枝杆菌感染不应再成为肺移植的绝对禁忌证。