高级前列腺上皮内瘤变（PIN）是非洲裔美国男性中与 PSA 无关的前列腺癌的危险因素：一项试点研究的结果。
High grade prostate intraepithelial neoplasia (PIN) is a PSA-independent risk factor for prostate cancer in African American men: results from a pilot study.
机构信息
Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa FL33612, USA.
出版信息
Cancer Lett. 2013 May 1;331(2):154-7. doi: 10.1016/j.canlet.2012.12.014. Epub 2012 Dec 23.
Abstract
African American men (AAM) demonstrate increased prostate cancer incidence and mortality rates. We investigated known prostate cancer risk factors in AAM. Prostate specific antigen (PSA) and diagnosis of high grade prostatic intraepithelial neoplasia (PIN) were significant prostate cancer predictors. However, even including AAM with low PSA (<4ng/ml), those with PIN had significantly elevated risk, compared to men without PIN (83.3% vs. 6.9%, p<0.0001). In AAM diagnosed with PIN, PSA level was no longer significant (83.3% vs. 92.3%, p=0.593 respectively). Our results suggest that a history of PIN is highly predictive of prostate cancer in AAM, and help provide PSA-independent venues for screening.
摘要
非裔美国男性（AAM）的前列腺癌发病率和死亡率均较高。我们研究了 AAM 中已知的前列腺癌危险因素。前列腺特异性抗原（PSA）和高级别前列腺上皮内瘤变（PIN）的诊断是前列腺癌的重要预测因素。然而，即使包括 PSA 水平较低（<4ng/ml）的 AAM 患者，与无 PIN 患者相比，AAM 中患有 PIN 的患者的风险显著升高（83.3% vs. 6.9%，p<0.0001）。在诊断为 PIN 的 AAM 患者中，PSA 水平不再具有显著意义（83.3% vs. 92.3%，p=0.593）。我们的研究结果表明，PIN 病史是 AAM 前列腺癌的高度预测因素，有助于提供与 PSA 无关的筛查途径。
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