Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Int J Urol. 2013 Aug;20(8):818-30. doi: 10.1111/iju.12048. Epub 2012 Dec 20.
To determine the efficacy and safety of the adrenergic alpha-antagonist tamsulosin in facilitating ureteral stones expulsion.
A literature search was carried out using the PubMed database, Medline via Ovid, Embase and the Cochrane Library database to identify randomized controlled trials evaluating the efficiency of tamsulosin in the treatment of ureteral stones. Meta-analysis and forest plots were carried out by use of Review Manager version 5.1 software (Cochrane Collaboration).
Compared with the control group, the tamsulosin group had an increase in expulsion rate of 51% and a decrease in expulsion time of 2.63 days. Furthermore, tamsulosin was found to reduce the risk of ureteral colic during treatment by 40% and also the risk of requirement of auxiliary procedures during follow up by 60%. In terms of safety, the tamsulosin group had a 117% increase in the incidence of side-effects compared with the control group, especially for incidence of dizziness.
Tamsulosin facilitates the expulsion of ureteral calculi by providing a higher expulsion rate, a shorter expulsion time, a lower incidence of ureteral colic during treatment and a lower requirement of auxiliary procedures. However, the incidence of dizziness occurring during tamsulosin treatment is significantly higher in this setting.
评估肾上腺素能α受体拮抗剂坦索罗辛促进输尿管结石排出的疗效和安全性。
检索 PubMed 数据库、Ovid 平台下的 Medline、Embase 和 Cochrane 图书馆，以评估坦索罗辛治疗输尿管结石的疗效。使用 Review Manager 5.1 软件进行荟萃分析和森林图绘制（Cochrane 协作网）。
与对照组相比，坦索罗辛组的排石率增加了 51%，排石时间缩短了 2.63 天。此外，坦索罗辛降低了治疗过程中输尿管绞痛的风险 40%，也降低了随访期间辅助治疗的风险 60%。安全性方面，坦索罗辛组的不良反应发生率比对照组增加了 117%，尤其是头晕的发生率。
坦索罗辛通过提高排石率、缩短排石时间、降低治疗过程中输尿管绞痛的发生率和减少辅助治疗的需求，促进输尿管结石的排出。然而，坦索罗辛治疗过程中头晕的发生率明显升高。
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