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特发性帕金森病下尿路功能障碍的有效管理。

Effective management of lower urinary tract dysfunction in idiopathic Parkinson's disease.

机构信息

Urology Department, King George Hospital, Barking, Havering and Redbridge University Teaching Hospitals NHS Trust, Essex, UK.

出版信息

Int J Urol. 2013 Jan;20(1):79-84. doi: 10.1111/j.1442-2042.2012.03220.x.

Abstract

Parkinson's disease, also known as paralysis agitans, is a progressive degenerative disorder of the central nervous system, with onset usually between the ages of 50 and 65 years, and is associated with loss of dopaminergic neurons in the subsantia nigra and the presence of Lewy bodies. It is characterized by the triad of resting tremor, muscular rigidity and bradykinesia. Often-accompanying abnormalities include disorders of equilibrium, posture and autonomic function, including micturition. Symptoms from the lower urinary tract add a significant comorbidity factor in these patients. The incidence and prevalence of lower urinary tract dysfunction rise with increasing progression of the underlying neurological disease. They present a troublesome and difficult to treat health issue with a profound impact on the patient's quality of life. Storage symptoms seem to predominate. In the long term, renal function might be compromised, mainly as a result of elevated intravesical pressure. Various conservative, minimally-invasive and surgical treatment options are available to prevent harmful sequelae, and to improve the quality of life of these patients. We present an overview of current and prospective treatment strategies.

摘要

帕金森病,又称震颤麻痹,是一种中枢神经系统的进行性退行性疾病,通常在 50 岁至 65 岁之间发病,与黑质中多巴胺能神经元的丧失和路易体的存在有关。其特征是静止性震颤、肌肉僵硬和运动迟缓三联征。常伴随的异常包括平衡、姿势和自主功能障碍,包括排尿。下尿路症状为这些患者增加了重要的合并症因素。随着潜在神经疾病的进展,下尿路功能障碍的发生率和患病率上升。它们表现为一种麻烦且难以治疗的健康问题,对患者的生活质量有深远影响。储存症状似乎更为突出。从长远来看,肾功能可能会受到损害,主要是由于膀胱内压升高所致。目前有各种保守、微创和手术治疗选择,可预防有害的后遗症,并改善这些患者的生活质量。我们介绍了当前和未来的治疗策略概述。

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