Roberts P M
Crit Care Nurse. 1990 Apr;10(4):38-9, 47-54.
NEC, a highly lethal disease that affects premature/compromised infants, is characterized by ischemic necrosis of the gastrointestinal tract. While risk factors can be identified, pathogenesis is uncertain. Protective factors in breast milk promote intestinal maturation and protect the newborn gut from pathologic penetration of macromolecules. Medical and surgical treatments have improved the prognosis of those diagnosed with NEC; however, prevention appears to be the most effective way to decrease mortality rates in the ever-increasing premature population.
坏死性小肠结肠炎(NEC)是一种影响早产/体弱婴儿的高致死性疾病,其特征为胃肠道缺血性坏死。虽然可以确定风险因素,但其发病机制尚不清楚。母乳中的保护因子可促进肠道成熟,并保护新生儿肠道免受大分子的病理性渗透。医学和手术治疗改善了NEC确诊患者的预后;然而,在不断增加的早产人群中,预防似乎是降低死亡率的最有效方法。