发现香豆素-依托泊苷杂合物体外抗乳腺癌的作用及其机制。
Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.
机构信息
Department of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India.
出版信息
Eur J Med Chem. 2013 Feb;60:120-7. doi: 10.1016/j.ejmech.2012.11.044. Epub 2012 Dec 8.
PMID:23287057
Abstract
Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines.
摘要
开发一种新的、针对乳腺癌的靶向药物，既能治疗激素受体（阳性和阴性）乳腺癌，又极具挑战性。分子杂交的概念使我们发现了一类新型的香豆素-单端孢菌素杂合体，作为一种新型的乳腺癌药物，它能选择性地诱导原发性和转移性乳腺癌细胞系凋亡。
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